CLIMB-OUT CHILD MICROBES PREDICT HOW TO STAY AWAY FROM OBESITY

Overweight affects greater than 50% of the EU populaon and contributes to the development of chronic metabolic (type-2 diabetes) and cardiovascular disorders, which are leading causes of morbidity and mortality worldwide. Child obesity is of special concern as the number of overweight children has increased 10 fold in the last 40 years and, of those, 60% are expected to remain overweigh in adulthood. CLIMB-OUT proposes (1) to develop microbiome-informed predicve tools for early detecon of obesity risk that facilitate the implementaon of lifestyle and dietary changes and (2) to co-design ad hoc educaonal and communicaon innovave programs to engage families and health care professionals in support for the adopon of healthy lifestyles across different societal environments. To this end, CLIMB-OUT will undertake a study of a large cohort of children in Southern European countries, which will be deeply phenotyped using the latest advances in omics technologies and arficial intelligence in order to validate the preliminary findings of the EU project MyNewGut. The ulmate goal is to facilitate early detecon of obesity risk and mely implementaon and adopon of healthier diet and lifestyles across different societal environments to reverse the obesity epidemic.