On the role of the entorhinal cortex in the effective connectivity of the hippocampal formation

López-Madrona, V.; Matias,F.; Pereda, E.; Canals, S.; Mirasso, C.
Chaos 27, 047401 (2017)

Find a relation between structural and functional brain connectivity is one of the
major goals of neuroscientists. In order to tackle this issue two questions can be addressed:
How do anatomical connections among brain regions influence the information
flow in the brain network? And, how to determine the structural connectivity from
the effective connectivity (or, more precisely, from causal measurements)? In this
work we model the hippocampal formation assuming three main areas (CA1, CA3 and
the dentate gyrus) and the enthorrinal cortex (EC), with the aim of exploring how the
structural connectivity between EC layers influences the causal links among these three
hippocampal regions. We apply two different statistical causality measurements to the
simulated neurophysiological time series: Granger Causality (GC) and Partial Transfer
Entropy (PTE). Our results reveal that the estimation of effective connectivity in
the hippocampus strongly depends on the connectivity among EC layers. We also find
that GC and PTE may yield very different results for certain configurations among the
layers of the EC. In addition, we show that based on GC and PTE measurements it is
not possible to differentiate between excitatory and inhibitory inter-areal connections.

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