Multicompartmental model of CA3 and CA1 hippocampal regions for studying rythms

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The hippocampus is one of the most studied brain areas in mammals and it plays a fundamental role in learning, memory and spatial navigation. Theta and gamma oscillations are the most prominent rhythms observed in freely moving animals in hippocampus. Although diverse computational models have been proposed to explain the existing theta-gamma interactions and their relation to cognitive functions, some questions remain open. Therefore, we are developing a multicompartmental model of the hippocampus CA3 and CA1 regions for the study of rhythm interacctions. We want to study how different patters of inputs, organized in gamma and theta sequences, and ariving from different afferent sources (CA3 and entorhinal cortex) to the dendritic tree of CA1 pyramidal neurons are integrated and transformed into a specific output. Understanding the intradendritic input/output transformation will contribute to unveil the computations supporting memory formation and navigation.

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Claudio Mirasso

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