In this presentation I will discuss research form our lab whereby computational models -supported by experiments- are used to provide new insights on how dendrites contribute to various brain functions. Specifically, I will present our findings on how dendritic nonlinearities in fast spiking interneurons and their can influence the processing abilities of these cells and the encoding of new memories, the role of human dendrites in enabling complex computations such as solving the XOR problem  and the contributions of dendrite-targeting interneurons on place cell dynamics in the hippocampus, in health  and disease .
 Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators. Nat Commun. 2019;  Dendritic action potentials and the computation in human layer 2/3 cortical neurons. Science, 367(6473):83-87;  Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning. Neuron. 2019;  Breakdown of spatial coding and interneuron synchronization in epileptic mice. Nat Neurosci. 2020.
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