Hypoxic response in cancer activation progression: modeling HIF.

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Meeting ID: 818 5624 9332

Passcode: 586157

The reprogramming of energy metabolism represents an important hallmark of cancer. The main cause of this alteration is represented by the presence of hypoxic areas. The decreased availability of oxygen activates the Hypoxia Inducible Factor (HIF) pathway which regulates the switch from an aerobic to an anaerobic metabolism, as well as an increased uptake of glucose.

The aim of this thesis is multiple. In the first part we study and we numerically simulate a mathematical model consisting of four ordinary differential equations (ODEs): one for cancer cells with HIF inactivated, one for cancer cells with HIF activated and two for the metabolites cancer cells can consume in order to produce ATP. We model the dynamics of the transition between the two different behaviors, of cancer growth under normoxic and hypoxic conditions and of cancer progression in a hostile environment; furthermore we compare the behaviour of cancer cells in highlanders and lowlanders.

Thesis advisors: Raúl Toral, Franco Flandoli

Jury: Emilio Hernández, Damià Gomila, Raúl Toral

Contact details:

Raúl Toral
971 17 32 35
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