Rhythmic and sequential subdivision of the elongating vertebrate embryonic body axis into morphological somites is controlled by an oscillating multicellular genetic network termed the segmentation clock. This clock operates in the presomitic mesoderm (PSM), generating dynamic stripe patterns of oscillatory gene-expression across the field of PSM cells. How these spatial patterns, the clock\'s collective period, and the underlying cellular-level interactions are related is not understood. In this talk we introduce a delayed coupling theory that represents the PSM as an array of phase oscillators, combining four key elements: a frequency profile of oscillators slowing across the PSM; coupling between neighboring oscillators; delay in coupling; and a moving boundary describing embryonic axis elongation. This theory combines several spatiotemporal aspects and predicts that the segmentation clock\'s collective period depends on delayed coupling, a prediction experimentally confirmed and that will be more carefully explained in Tuesday\'s seminar by Andrew Oates.
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