We will present recent work on two biomedical examples of protein aggregation from aqueous solutions. The first is a model that can predict the formation of a fractal network of insulin monomers and the subsequent break-up of the fractal network into microspherical aggregates. The results of our study capture the main features of a recent experimental study of insulin microcrystal precipitation. The second is a theoretical calculation of the critical bundle size of sickle hemoglobin chains. The formation of these bundles is thought to be the crucial kinetic process that leads to sickle cell anemia.
Coffee and cookies will be served 15 minutes before the start of the seminar
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