Drug absorption through a cell monolayer: A theoretical work on a non-linear three-compartment model

• DOI: 10.1016/j.ejps.2009.01.005
• ArXiv number: 0805.3757

The subject of analysis is a non-linear three-compartment model, widely used in pharmacological absorption studies. It has been transformed into a general form, thus leading
automatically to an appropriate approximation. This made the absorption profile accessible and expressions for absorption times, apparent permeabilities and equilibrium values
were given. These findings allowed a profound analysis of results from non-linear curve
fits and delivered the dependencies on the systems’ parameters over a wide range of values.
The results were applied to an absorption experiment with multidrug transporter-affected
antibiotic CNV97100 on Caco-2 cell monolayers.

• Full paper

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