In this presentation I will discuss research form our lab whereby computational models -supported by experiments- are used to provide new insights on how dendrites contribute to various brain functions. Specifically, I will present our findings on how dendritic nonlinearities in fast spiking interneurons and their can influence the processing abilities of these cells and the encoding of new memories[1], the role of human dendrites in enabling complex computations such as solving the XOR problem [2] and the contributions of dendrite-targeting interneurons on place cell dynamics in the hippocampus, in health [3] and disease [4].
[1] Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators. Nat Commun. 2019; [2] Dendritic action potentials and the computation in human layer 2/3 cortical neurons. Science, 367(6473):83-87; [3] Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning. Neuron. 2019; [4] Breakdown of spatial coding and interneuron synchronization in epileptic mice. Nat Neurosci. 2020.
Zoom
https://us02web.zoom.us/j/81586640764?pwd=T1lMM0QzSnFSNjYxOHlLN0VNcTY2Zz09
Meeting id: 815 8664 0764
Pass Code: 784372
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