A network perspective on metabolic inconsistency

Comparing gene expression profiles with metabolic pathways under different experimental conditions is helpful for understanding how the conditions affect the coherence of these two layers of cellular organization. Here we compare two recent approaches for such a comparison and find a surprisingly strong negative correlation of a inconsistency measure [1], obtained by context-specific flux balance analysis, and the metabolic coherence [2], which relies solely on metabolic network topology, both measuring the coherence of gene expression and metabolic needs.

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