presentation/291 1st BioSim Conference - Presentation

1st BioSim Conference


A Framework for Whole-Body Modelling

Author: Mads Madsen, University of Copenhagen.

Names and affiliation of other authors:
M. F. Madsen, S. Danø, P.G. Sørensen & B. Quistorff
University of Copenhagen

Oral or poster: Oral presentation

We propose an alternative strategy for the development of whole-body models. The approach is a modular approach constrained by available physiological data. The physiological data used to constrain the model is stationary state fluxes and concentrations at a specific, well defined physiological operating point. Here we outline this approach by presenting two simple modelling frameworks corresponding to two such well-defined physiological states. These are an early postabsorptive phase, where glycogen is being synthesised in both liver and muscle, and a state corresponding to 36 hours of starvation where the glycogen stores in both liver and muscle have been used up.
The advantage of the strategy which we are proposing is that the daunting task of whole-body modelling can be attacked in a stepwise manner. At
first whole-body models can be developed using either simplified kinetics or existing biochemical models for each of the specific organs. The level of detail of each of these specific biochemical models can be expanded as needed, without the need of changing the entire whole-body model. This modular modelling strategy is well-suited for development of whole-body models through a collaboration between different research groups.

1st BioSim Conference. October 6th to October 8th, 2005. Palma de Mallorca, Spain.