presentation/230 1st BioSim Conference - Presentation

1st BioSim Conference


Comparative study of xenobiotic metabolism in Saccharomyces cerevisiae yeast cells and human Hep G2 liver cells

Author: Jörg Smolinski and Martin Bertau, Technical University Dresden, Institute of Biochemistry.

Names and affiliation of other authors:
Technische Universität Dresden, Institut für Biochemie, 01062 Dresden, Germany

Oral or poster: Poster

Prediction of metabolic fate of drugs and pharmaceutical active compounds in preclinical studies is the aim of the ongoing work. Therefore the yeast Saccharomyces cerevisiae, a fungus sharing elementary features with mammalian cells, serves as model organism and the flux cell model described by Brusch et al. was used to predict potential outcomes of vertebrate drug metabolism. Several -ketoesters with different functional groups were used as model substrates to study metabolic processes of pharmaceutical active compounds in yeast and liver cells.

Brusch L. et. al., Biophys Chem. 109(3) 2004, 413-426

Formatted version of the abstract or additional information

1st BioSim Conference. October 6th to October 8th, 2005. Palma de Mallorca, Spain.