Author: Jörg Smolinski and Martin Bertau, Technical University Dresden, Institute of Biochemistry.
Names and affiliation of other authors:
Technische Universität Dresden, Institut für Biochemie, 01062 Dresden, Germany
Oral or poster: Poster
Prediction of metabolic fate of drugs and pharmaceutical active compounds in preclinical studies is the aim of the ongoing work. Therefore the yeast Saccharomyces cerevisiae, a fungus sharing elementary features with mammalian cells, serves as model organism and the flux cell model described by Brusch et al. was used to predict potential outcomes of vertebrate drug metabolism. Several -ketoesters with different functional groups were used as model substrates to study metabolic processes of pharmaceutical active compounds in yeast and liver cells.
Brusch L. et. al., Biophys Chem. 109(3) 2004, 413-426