presentation/219 1st BioSim Conference - Presentation

1st BioSim Conference

Presentation

Toward multiscale modeling of deep brain stimulation in Parkinson’s disease

Author: J. Modolo/A. Beuter, Institute of Cognitive Sciences.

Names and affiliation of other authors:
Modolo, Julien; Henry, Jacques; Garenne, André; Beuter, Anne
Julien Modolo and Anne Beuter Institut de Cognitique, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux
email: modolo@idc.u-bordeaux2.fr; and beuter@idc.u-bordeaux2.fr
Jacques Henry INRIA, Université de Bordeaux 1, 351, Cours de la libération, 33405 Talence
email: Jacques.Henry@inria.fr
André Garenne INSERM Université de Bordeaux 2
email: Andre.Garenne@bordeaux.inserm.fr

Oral or poster: Oral presentation

Abstract:
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become a recognized surgical procedure for symptomatic treatment of advanced Parkinson´s Disease. However biological mechanisms underlying motor symptoms improvements are still poorly understood. We present the basis of a biologically plausible large-scale basal ganglia model and based on the population density approach and the Izhikevich model. This should allow us to test the validity of different DBS mechanisms hypotheses.

1st BioSim Conference. October 6th to October 8th, 2005. Palma de Mallorca, Spain.