Effects of circadian disruption through chronic jet-lag on oxaliplatin chronopharmacology in mice.
Author: Elisabeth Filipski, INSERM.
Names and affiliation of other authors: Jennyfer Carrière and Francis Lévi INSERM
Oral or poster: Oral presentation
Abstract: Oxaliplatin toxicity and efficacy displayed circadian rhythms in mice and in cancer patients. Chronic jet-lag (CJL) induced disruption of molecular circadian and cell cycle rhythms that accelerated tumor growth in mice. We studied the effect of CJL on oxaliplatin toxicity in mice. Results: disruption of the circadian timing system did not modify drug toxicity rhythm, but enhanced its overall toxicity through a decrease in the expression of DNA-repair genes ERCC1 and XPA.