Presentation
Effects of circadian disruption through chronic jet-lag on oxaliplatin chronopharmacology in mice.
Author: Elisabeth Filipski, INSERM.
Names and affiliation of other authors:
Jennyfer Carrière and Francis Lévi
INSERM
Oral or poster: Oral presentation
Abstract:
Oxaliplatin toxicity and efficacy displayed circadian rhythms in mice and in cancer patients. Chronic jet-lag (CJL) induced disruption of molecular circadian and cell cycle rhythms that accelerated tumor growth in mice. We studied the effect of CJL on oxaliplatin toxicity in mice. Results: disruption of the circadian timing system did not modify drug toxicity rhythm, but enhanced its overall toxicity through a decrease in the expression of DNA-repair genes ERCC1 and XPA.
1st BioSim Conference. October 6th to October 8th, 2005. Palma de Mallorca, Spain.