presentation/211 1st BioSim Conference - Presentation

1st BioSim Conference

Presentation

Effects of circadian disruption through chronic jet-lag on oxaliplatin chronopharmacology in mice.

Author: Elisabeth Filipski, INSERM.

Names and affiliation of other authors:
Jennyfer Carrière and Francis Lévi
INSERM

Oral or poster: Oral presentation

Abstract:
Oxaliplatin toxicity and efficacy displayed circadian rhythms in mice and in cancer patients. Chronic jet-lag (CJL) induced disruption of molecular circadian and cell cycle rhythms that accelerated tumor growth in mice. We studied the effect of CJL on oxaliplatin toxicity in mice. Results: disruption of the circadian timing system did not modify drug toxicity rhythm, but enhanced its overall toxicity through a decrease in the expression of DNA-repair genes ERCC1 and XPA.

Formatted version of the abstract or additional information

1st BioSim Conference. October 6th to October 8th, 2005. Palma de Mallorca, Spain.