Presentation
Dynamics robustness of cellular function
Author: FJ Bruggeman, Molecular Cell Physiology, Vrije universiteit, Amsterdam, 2. Manchester Centre for Integrative Systems Biology , Manchester I.
Names and affiliation of other authors:
HV Westerhoff
1. Molecular Cell Physiology, Vrije universiteit, Amsterdam, The Netherlands
2. Manchester Centre for Integrative Systems Biology
Manchester Interdisciplinary Biocentre (MIB)
University of Manchester
Manchester, United Kingdom
Oral or poster: Oral presentation
Abstract:
Cells in general, and unicellular organisms in particular, are continously challenged by changes in their environment. Those changes can be beneficial, or hazardous. Often cells respond by adapting their physiology in such a way that some of its functions change while some remain invariant. The latter functions are then robust whereas the former ones are fragile. I will introduce methods to analyze and explain robustness in terms of the network topology and its dynamic organization.